The Bernie Mac Show (often shortened to Bernie Mac in syndication) is an American sitcom that aired on Fox for five seasons from November 14, 2001, to April 14, 2006. The series featured comic actor Bernie Mac and his wife Wanda raising his sisters three kids: Jordan, Vanessa, and Bryana.

The series was loosely based on Macs stand-up comedy acts. In real life, Bernie Mac McCullough was married with one daughter; Macs character on the show (a stand-up comedian) was married with no children of his own. The pilot episode, aired on November 14, 2001, set up the basic premise for the series: the character Bernie Mac takes in his sisters children after she enters rehab (a premise taken from one of Macs routines in the 2000 film, The Original Kings of Comedy).

Much of the humor in the show was derived from Macs continual adjustment to and his unique take on parenthood. A frequent motif of the show was the juxtaposition of Macs acerbic comments, such as his threats to bust the (childrens) heads til the white meat shows, and the deep parental affection he felt towards the trio, which often brought him to the verge of tears during happy moments. Towards the end of the series, Bryanas long-lost father (Anthony Anderson) returns and drops by from time to time to help Bernie and Wanda with the kids.

Many of his most emotional scenes occurred in segments in which Mac, while still in character, broke the fourth wall and talked to the television audience, which he referred to as America. This technique was most notably used before an episode during the 2005-2006 season, when Bernie, as himself and wearing a Chicago White Sox cap and jacket, delivered a heartfelt congratulatory message to the baseball organization and its staff on their recent World Series Championship. Bernie, who grew up on Chicagos south-side, was a die-hard fan of the White Sox and was seen at Game 1 of the World Series, in a front row seat. As was also the case during his stand-up routine, Mac habitually addressed the audience as America